SYMPOSIA PAPER Published: 01 January 1992

Clinical and Experimental Studies in the Biology of Aseptic Loosening of Joint Arthroplasties and the Role of Polymer Particles


Aseptic loosening is the most common cause of failure of joint arthroplasties. Although the exact pathogenesis of the loosening process is not completely understood, particles of polymethyl methacrylate and polyethylene appear to play a crucial role. This paper summarizes past and current clinical and experimental research on the biology of aseptic loosening of joint arthroplasties and discusses the important role of particulate polymeric debris.

Author Information

Goodman, SB
Stanford University Medical Center, Stanford, CA
Fornasier, VL
Bone and Joint Research Laboratory, Department of Pathology, The Princess Margaret and Wellesley Hospitals, University of Toronto, Toronto, Canada
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Developed by Committee: F04
Pages: 27–37
DOI: 10.1520/STP14849S
ISBN-EB: 978-0-8031-5202-1
ISBN-13: 978-0-8031-1441-8