SEDL / STP / STP898-EB / STP33294S

Acellular Vascular Matrix as a Small Diameter Vascular Graft

Brendel, K
Professor and research associate professor, College of Medicine, University of Arizona, Tucson, AZ

Duhamel, RC
Professor and research associate professor, College of Medicine, University of Arizona, Tucson, AZ

Malone, JM
Associate professor and research assistant, College of Medicine, University of Arizona, Tucson, AZ

Reinert, RL
Associate professor and research assistant, College of Medicine, University of Arizona, Tucson, AZ

Pages: 17    Published: Jan 1986

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Abstract

Extraction of soft tissues with detergents yield histoarchitecturally intact extracellular matrix frameworks of the original tissue. When applied to dog carotid arteries, this procedure results in acellular vascular matrix (AVM) tubes that retain the physical properties of the original artery. This material is less thrombogenic than a number of other graft materials. The internal diameter of greyhound AVM averages 3.0 mm under physiological pressure. Carotid interposition grafts of 10 cm of noncross-linked AVM exhibit an overall patency of 75% at 150 days. Cross-carotid grafts of 15 cm of noncross-linked AVM implanted for 18 months were fully endothelialized as shown by histology, scanning electron microscopy (SEM), and factor VIII staining.