Standard test method for determination of ammonium and sulfate ions in liposomal-doxorubicin formulation in three different cases: 1) total amount of ammonium and sulfate, 2) amount of ammonium and sulfate inside liposome, and 3) amount of ammonium and sulfate outside liposome.
entrapped ions; ion chromatography; separating entrapped and free ions
Doxorubicin is actively loaded into liposomes by using transmembrane ammonium sulfate gradient. Ammonium and sulfate ion are important in determining stability of the doxorubicin liposomal formulation therefore a robust and standardized analytical method for determining their concentration is useful for drug manufacturers, clinicians as well as academic researchers.
The title and scope are in draft form and are under development within this ASTM Committee.
Date Initiated: 04-21-2023
Technical Contact: Arjun Sharmah
Item: 000
Ballot:
Status: