Polyether polyurethane concrete (PPC) is a new type of cold-mixed and cold-paved material, and its strength increases with the curing time. Although its final mechanical strength was relatively high, traffic can only be opened after reaching a certain strength during the curing period. In this study, indirect tensile strength was selected as the evaluation indicator to determine the traffic opening timing. Four mixture performance tests, including the rutting test, moisture susceptibility test, low-temperature bending test, and fatigue cracking test, were conducted on PPC specimens with different indirect tensile strengths to determine the optimal traffic opening timing for PPC. Then, this proposed traffic opening timing model was verified based on an accelerated pavement testing. The test results show that the indirect tensile strength of 2.1 MPa was considered as the minimum traffic opening strength. When the indirect tensile strength of PPC was larger than 2.1 MPa, the performance of PPC could meet all the specified requirements of the mixture, and the impact of opening traffic on the final strength and fatigue life of PPC at this moment was less than 4 % and 5 %, respectively.