Journal Published Online: 01 September 2004
Volume 49, Issue 5

Accidental Insulin Overdose



Exogenous insulin has been used for many years to treat diabetes mellitus. Due to the complex nature of insulin therapy, there have been numerous accidental overdoses by these patients. Unfortunately, in other instances, insulin has been used as an agent for suicide and homicide in diabetics as well as nondiabetics. Presented here is a fatal case of accidental insulin overdose in a nondiabetic. Following the case presentation, we review insulin pharmacology and the methods of diagnosing insulin overdose postmortem. In any case of insulin overdose, a comprehensive scene investigation to document the amount and type of insulin used, along with information revealing the source of the insulin is critical. In addition, a complete autopsy, including appropriate laboratory studies, is needed to make a diagnosis in these cases. Proper attention should be given to collection and storage of blood samples, as these specimens often yield the strongest evidence of insulin overdose.

Author Information

Batalis, NI
Medical University of South Carolina, Children's Hospital, Charleston, SC
Prahlow, JA
South Bend Medical Foundation and Indiana University School of Medicine, South Bend Center for Medical Education, South Bend, IN
Pages: 4
Price: $25.00
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Stock #: JFS2004059
ISSN: 0022-1198
DOI: 10.1520/JFS2004059