Journal Published Online: 01 January 1982
Volume 27, Issue 1

Approaches to Drug Sample Differentiation. III: A Comparative Study of the Use of Chiral and Achiral Capillary Column Gas Chromatography/Mass Spectrometry for the Determination of Methamphetamine Enantiomers and Possible Impurities

CODEN: JFSCAS

Abstract

A gas chromatograph/mass spectrometer (GC/MS) system equipped with a chiral and an achiral capillary column is used to analyze control methamphetamine, an illicit methamphetamine preparation (“White Cross”), and a simulated illicit methamphetamine synthesis product. Samples are derivatized with N-trifluoroacetyl-l-prolyl chloride (I-TPC) before the GC/MS analysis. The results obtained lead to the conclusion that the resolution on an achiral column is adequate for the determination of methamphetamine enantiomers and impurities, providing the enantiomeric impurity of the l-TPC is known. Four new possible by-products of methamphetamine preparations were identified in the simulated illicit methamphetamine synthesis product.

Author Information

Liu, JH
University of Illinois at Chicago Circle, Chicago, IL.
Ku, WW
University of Illinois at Chicago Circle, Chicago, IL.
Tsay, JT
University of Illinois at Chicago Circle, Chicago, IL.
Fitzgerald, MP
University of Illinois at Chicago Circle, Chicago, IL.
Kim, S
Central Regional Laboratory, Environmental Protection Agency, Chicago, IL.
Pages: 10
Price: $25.00
Related
Reprints and Permissions
Reprints and copyright permissions can be requested through the
Copyright Clearance Center
Details
Stock #: JFS11449J
ISSN: 0022-1198
DOI: 10.1520/JFS11449J