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Significance and Use
5.1 A tiered strategy for characterization of nanoparticle properties is necessary to draw meaningful conclusions concerning dose-response relationships observed during inhalation toxicology experiments. This tiered strategy includes characterization of nanoparticles as produced (that is, measured as the bulk material sold by the supplier) and as administered (that is, measured at the point of delivery to a test subject) (Oberdorster et al., 2005) (6).
5.2 Test Methods B922 and C1274 and ISO Standards 9277 and 18757 exist for determination of the as produced surface area of bulk metal and metal oxide powders. During the delivery of metal and metal oxide nanoparticles in inhalation exposure chambers, the material properties may undergo change and therefore have properties that differ from the material as produced. This test method describes the determination of the as administered surface area of airborne metal and metal oxide nanoparticles in inhalation exposure chambers for inhalation toxicology studies.
1.1 This test method covers determination of surface area of airborne metal and metal oxide nanoparticles in inhalation exposure chambers for inhalation toxicology studies. Surface area may be measured by gas adsorption methods using adsorbates such as nitrogen, krypton, and argon (Brunauer et al., 1938; Anderson, 1975; Gregg and Sing, 1982) (1, 2, 3)2 or by ion attachment and mobility-based methods (Ku and Maynard, 2005) (4). This test method is specific to the measurement of surface area by gas adsorption by krypton gas adsorption. The test method permits the use of any modern commercial krypton adsorption instruments but strictly defines the sample collection, outgassing, and analysis procedures for metal and metal oxide nanoparticles. Use of krypton is required due to the low overall surface area of particle-laden samples and the need to accurately measure the background surface area of the filter used for sample collection. Instrument-reported values of surface area based on the multipoint Brunauer, Emmett and Teller (BET) equation (Brunauer et al., 1938; Anderson, 1975; Gregg and Sing, 1982) (1, 2, 3) are used to calculate surface area of airborne nanoparticles collected on a filter.
1.2 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. State all numerical values in terms of SI units unless specific instrumentation software reports surface area using alternate units.
1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.
2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.
B922 Test Method for Metal Powder Specific Surface Area by Physical Adsorption
C1274 Test Method for Advanced Ceramic Specific Surface Area by Physical Adsorption
E691 Practice for Conducting an Interlaboratory Study to Determine the Precision of a Test Method
E2456 Terminology Relating to Nanotechnology
ISO StandardsISO18757 Fine Ceramics (Advanced Ceramics, Advanced Technical Ceramics)--Determination of Specific surface Area of Ceramic Powders by Gas Adsorption using the BET Method ISO9277 Determination of the Specific Surface Area of Solids by Gas Adsorption using the BET Method
ICS Number Code 07.030 (Physics. Chemistry); 49.025.05 (Ferrous alloys in general)
UNSPSC Code 12142003(Krypton gas Kr)