Volume 3, Issue 7 (July 2006)

    Assessing Human Exposure to Perchlorate Using Biomonitoring

    (Received 13 December 2005; accepted 18 April 2006)

    CODEN: JAIOAD

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    Abstract

    Because of health concerns surrounding widespread exposure to perchlorate, we developed a sensitive and selective method for measuring perchlorate in human urine using ion chromatography coupled with electrospray ionization tandem mass spectrometry. This method was applied to assess perchlorate levels in urine collected from a convenience population (N=27) consuming foods reported to contain perchlorate: milk, dairy products, and green leafy vegetables. Consumption of three or more servings of these foods in the 16 hours before urine sample collection was associated with significantly higher levels of perchlorate in urine (6.13±3.59 μg/g creatinine) compared with study participants consuming one or fewer servings of these foods (3.14±0.85 μg/g creatinine). These data suggest that diet can be an important source of perchlorate exposure and underscore the important role of selective and sensitive biomonitoring methods to assess human exposure to perchlorate from multiple sources in the environment.


    Author Information:

    Blount, BC
    Lead Research Chemist, Emergency Response and Air Toxicants Branch, Centers for Disease Control and Prevention, Atlanta, GA

    Valentín-Blasini, L
    Research Chemist, Emergency Response and Air Toxicants Branch, Centers for Disease Control and Prevention, Atlanta, GA

    Ashley, DL
    Chief, Emergency Response and Air Toxicants Branch, Centers for Disease Control and Prevention, Atlanta, GA


    Stock #: JAI100398

    ISSN: 1546-962X

    DOI: 10.1520/JAI100398

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    Author
    Title Assessing Human Exposure to Perchlorate Using Biomonitoring
    Symposium Perchlorate: Exposure from Food and the Environment, 2006-02-09
    Committee D18