Journal Published Online: 01 July 1980
Volume 25, Issue 3

Identification of Dextropropoxyphene and Its Diastereoisomers

CODEN: JFSCAS

Abstract

The specific diastereoisomer of a suspected propoxyphene sample can be identified by thin-layer chromatography, infrared spectroscopy, or nuclear magnetic resonance. If the sample is α-propoxyphene, the optical isomer must be identified by crystal tests, polarimetry, or melting point. This paper describes spectroscopic methods and physical properties that can be used to identify the four diastereoisomers and two racemates of propoxyphene. Of the four diastereoisomers, only the controlled α-d-propoxyphene and the noncontrolled α-l-propoxyphene forms are commercially available.

Author Information

Newby, NR
Drug Enforcement Administration, Mid-Atlantic Regional Laboratory, Washington, D.C.
Hughes, RB
Drug Enforcement Administration, Mid-Atlantic Regional Laboratory, Washington, D.C.
Pages: 9
Price: $25.00
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Stock #: JFS11269J
ISSN: 0022-1198
DOI: 10.1520/JFS11269J