Identification of Dextropropoxyphene and Its Diastereoisomers

    Volume 25, Issue 3 (July 1980)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 July 1980

    Page Count: 9


    Newby, NR
    Forensic chemists, Drug Enforcement Administration, Mid-Atlantic Regional Laboratory, Washington, D.C.

    Hughes, RB
    Forensic chemists, Drug Enforcement Administration, Mid-Atlantic Regional Laboratory, Washington, D.C.

    (Received 20 March 1979; accepted 17 November 1979)

    Abstract

    The specific diastereoisomer of a suspected propoxyphene sample can be identified by thin-layer chromatography, infrared spectroscopy, or nuclear magnetic resonance. If the sample is α-propoxyphene, the optical isomer must be identified by crystal tests, polarimetry, or melting point. This paper describes spectroscopic methods and physical properties that can be used to identify the four diastereoisomers and two racemates of propoxyphene. Of the four diastereoisomers, only the controlled α-d-propoxyphene and the noncontrolled α-l-propoxyphene forms are commercially available.


    Paper ID: JFS11269J

    DOI: 10.1520/JFS11269J

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    Author
    Title Identification of Dextropropoxyphene and Its Diastereoisomers
    Symposium , 0000-00-00
    Committee E30