ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 January 1985
Page Count: 4

Fatal Malignant Hyperthermia as a Result of Ingestion of Tranylcypromine (Parnate®) Combined with White Wine and Cheese
Mirchandani, H
Deputy chief medical examiner and resident in forensic pathology, Wayne County Medical Examiner's Office, MI

Reich, LE
Deputy chief medical examiner and resident in forensic pathology, Wayne County Medical Examiner's Office, MI

(Received 30 April 1984; accepted 21 June 1984)

Abstract

Fatal malignant hyperthermia occurred in a patient who was taking tranylcypromine (Parnate®) and ingested wine and cheese. The case findings are presented along with a review of the literature concerning adverse interactions between monoamine oxidase (MAO) inhibitors and certain foods and beverages. Hyperthermia and its possible causative mechanisms and treatments are discussed. The facts suggest that the complicated dietary restrictions attending the use of MAO inhibitors and the possibility of severe and even catastrophic reactions resulting from violations of these restrictions make the use of these drugs fraught with danger and therefore not a first choice for the treatment of depression.

Keywords:
toxicology, tranylcypromine, hyperthermia

Paper ID: JFS10984J
DOI: 10.1520/JFS10984J
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