ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 January 1977
Page Count: 4

Metabolite Sensitivity in the Methaqualone Radioimmunoassay
Dominguez, AM
Members of the Division of Toxicology, of which Colonel Dominguez is Chief, the Armed Forces Institute of Pathology,

Keppler, BR
Members of the Division of Toxicology, of which Colonel Dominguez is Chief, the Armed Forces Institute of Pathology,

Manders, WW
Members of the Division of Toxicology, of which Colonel Dominguez is Chief, the Armed Forces Institute of Pathology,

(Received 26 April 1976; accepted 21 July 1976)

Abstract

The use of radioimmunoassay (RIA) as a method capable of detecting nanogram-per-millilitre (ng/ml) quantities of methaqualone in biological specimens has been described previously [1,2]. Several authors have shown, by using gas chromatography or mass spectrometry, or both, that the principal products of methaqualone metabolism, as they appear in the urine, are primarily the monohydroxy derivatives [3–5]. These derivatives have been found to be conjugated mainly with glucuronic acid. In this study the relative sensitivity of methaqualone and its metabolites to the RIA assay was investigated.

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Paper ID: JFS10387J
DOI: 10.1520/JFS10387J
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