Metabolite Sensitivity in the Methaqualone Radioimmunoassay

    Volume 22, Issue 1 (January 1977)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 January 1977

    Page Count: 4


    Dominguez, AM
    Members of the Division of Toxicology, of which Colonel Dominguez is Chief, the Armed Forces Institute of Pathology, Washington, D.C.,

    Keppler, BR
    Members of the Division of Toxicology, of which Colonel Dominguez is Chief, the Armed Forces Institute of Pathology, Washington, D.C.,

    Manders, WW
    Members of the Division of Toxicology, of which Colonel Dominguez is Chief, the Armed Forces Institute of Pathology, Washington, D.C.,

    (Received 26 April 1976; accepted 21 July 1976)

    Abstract

    The use of radioimmunoassay (RIA) as a method capable of detecting nanogram-per-millilitre (ng/ml) quantities of methaqualone in biological specimens has been described previously [1,2]. Several authors have shown, by using gas chromatography or mass spectrometry, or both, that the principal products of methaqualone metabolism, as they appear in the urine, are primarily the monohydroxy derivatives [3–5]. These derivatives have been found to be conjugated mainly with glucuronic acid. In this study the relative sensitivity of methaqualone and its metabolites to the RIA assay was investigated.


    Paper ID: JFS10387J

    DOI: 10.1520/JFS10387J

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    Author
    Title Metabolite Sensitivity in the Methaqualone Radioimmunoassay
    Symposium , 0000-00-00
    Committee E30