The Identification of Impurities in Illicit Methamphetamine Exhibits by Gas Chromatography/Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy

    Volume 22, Issue 1 (January 1977)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 January 1977

    Page Count: 13


    Kruegel, AV
    Forensic chemists, Special Testing and Research Laboratory, Drug Enforcement Administration, McLean, Va.

    Kram, TC
    Forensic chemists, Special Testing and Research Laboratory, Drug Enforcement Administration, McLean, Va.

    (Received 16 April 1976; accepted 19 May 1976)

    Abstract

    Methamphetamine, a drug frequently abused in the United States, is often manufactured illicitly. One method commonly employed for this purpose is the Leuckart reaction, which is initiated with methyl benzyl ketone (IV) and either methylamine (I) and formic acid (II) or N-methylformamide (III), producing N-formylmethamphetamine (IX) as an intermediate [1]. Hydrolysis of IX with a strong acid such as hydrochloric acid produces methamphetamine (VI). (See Table 1 for a list of abbreviations and Fig. 1 for corresponding structures.) As the synthesis proceeds, various impurities are accumulated: reactants, byproducts, and intermediates, as well as contaminants arising from within the reagents themselves. The identification of such impurities thus far encountered in this laboratory by gas chromatography/mass spectrometry (GC/MS) and nuclear magnetic resonance (NMR) spectroscopy will be the subject of this discussion.


    Paper ID: JFS10366J

    DOI: 10.1520/JFS10366J

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    Title The Identification of Impurities in Illicit Methamphetamine Exhibits by Gas Chromatography/Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy
    Symposium , 0000-00-00
    Committee E30