The development of standards and guidance for nanotechnology & nanomaterials, and 2) the coordination of existing ASTM standardization related to nanotechnology needs. This coordination shall include the apportioning of specific requests for nanotechnology standards through ASTM's existing committee base, as well as the maintenance of appropriate global liaison relationships with activities (internal and external) related to this subject area. The Committee shall participate in the development of symposia, workshops, and other related activities to enhance the development of standards.
platelets; nanoparticles; infusion reactions; reactogenicity; thrombogenicity
Platelet activation is an important prerequisite for blood coagulation. Undesirable blood coagulation may lead to thrombosis; likewise, undesirable inhibition of the blood coagulation may lead to hemorrhage. Besides participating in the blood coagulation, platelets secrete cytokines and participate in the overall inflammatory response. Platelet activation is known to contribute to the infusion reactions to nanomedicines. This document discusses procedure for the analysis of platelet activation and aggregation as a part of the assessment of nanoparticles' ability to cause infusion reactions
The title and scope are in draft form and are under development within this ASTM Committee.
Date Initiated: 05-12-2021
Technical Contact: Marina Dobrovolskaia
Item: 004
Ballot: E56.03 (21-02)
Status: Negative Votes Need Resolution