Work Item
ASTM WK76878

New Practice for the analysis of nanoparticle effects on human platelets in vitro

1. Scope

The development of standards and guidance for nanotechnology & nanomaterials, and 2) the coordination of existing ASTM standardization related to nanotechnology needs. This coordination shall include the apportioning of specific requests for nanotechnology standards through ASTM's existing committee base, as well as the maintenance of appropriate global liaison relationships with activities (internal and external) related to this subject area. The Committee shall participate in the development of symposia, workshops, and other related activities to enhance the development of standards.


platelets; nanoparticles; infusion reactions; reactogenicity; thrombogenicity


Platelet activation is an important prerequisite for blood coagulation. Undesirable blood coagulation may lead to thrombosis; likewise, undesirable inhibition of the blood coagulation may lead to hemorrhage. Besides participating in the blood coagulation, platelets secrete cytokines and participate in the overall inflammatory response. Platelet activation is known to contribute to the infusion reactions to nanomedicines. This document discusses procedure for the analysis of platelet activation and aggregation as a part of the assessment of nanoparticles' ability to cause infusion reactions

The title and scope are in draft form and are under development within this ASTM Committee.


Developed by Subcommittee: E56.03

Committee: E56

Staff Manager: Kathleen Chalfin

Work Item Status

Date Initiated: 05-12-2021

Technical Contact: Marina Dobrovolskaia

Item: 004

Ballot: E56.03 (21-02)

Status: Negative Votes Need Resolution