Work Item
ASTM WK76860

New Practice for the Preparation and Analysis of Culture Supernatants for the Presence of Cytokine Biomarkers by Nanoparticles in Human Whole Blood Cultures

1. Scope

The development of standards and guidance for nanotechnology & nanomaterials, and 2) the coordination of existing ASTM standardization related to nanotechnology needs. This coordination shall include the apportioning of specific requests for nanotechnology standards through ASTM's existing committee base, as well as the maintenance of appropriate global liaison relationships with activities (internal and external) related to this subject area. The Committee shall participate in the development of symposia, workshops, and other related activities to enhance the development of standards.

Keywords

nanomaterials; cytokines; infusion reactions; cytokine storm; vaccine efficacy

Rationale

This work item provides critical information for the characterization of immunological responses to nanomaterials including more recent COVID-vaccines. Specifically, side-effects reported in response to mRNA COVID vaccines, resemble infusion reactions, and therefore, these same work items apply to the characterization of lipid nanoparticle based mRNA vaccines.

The title and scope are in draft form and are under development within this ASTM Committee.

Details

Developed by Subcommittee: E56.03

Committee: E56

Staff Manager: Kathleen Chalfin

Work Item Status

Date Initiated: 05-10-2021

Technical Contact: Marina Dobrovolskaia

Item: 003

Ballot: E56.03 (21-02)

Status: Negative Votes Need Resolution