This paper is a controlled extended service interval (ESI) study of the comparative behaviors of a nitrite/borate/low-silicate, low total dissolved solids (TDS) coolant maintained with delayed-release filters, and an organic acid inhibited coolant technology in heavy-duty engines. It reports both laboratory and fleet test data from 66 trucks, powered with different makes of heavy-duty diesel engines. The engines were cooled with three different types of inhibitors and two different glycol base (ethylene glycol and propylene glycol) coolants for an initial period exceeding two years and 500 000 km (300 000 miles). The data reported include chemical depletion rates, periodic coolant chemical analyses, and engine/cooling system reliability experience. The ongoing test will continue for approximately five years and a 1.6 million km (1 million miles) duration. Thirteen trucks were retained as controls, operating with ASTM D 4985 specification (GM-6038 type) coolant maintained with standard ASTM D 5752 supplemental coolant additive (SCA). Engines produced by Caterpillar, Detroit Diesel Corp., Cummins Engine Co., and Mack Trucks are included in the test mix.