SYMPOSIA PAPER Published: 01 January 1988
STP34042S

Implications of Molecular Speciation and Topology of Environmental Metals: Uptake Mechanisms and Toxicity of Organotins

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This paper compares predictions of environmental fate and effect parameters derived from quantitative structure-activity relationships (QSAR) using estimates of molecular total surface area (TSA) with experimental data. Organotins are used as an example. In addition, a simple linear free-energy relationship with TSA is demonstrated to be applicable to organotin aqueous solubility, chromatographic retentivity, octanol-water partition coefficients and bacterial uptake, and aquatic toxicity. New measurement methodology providing nondestructive optical imaging in vivo of tin employing a fluorescent, tin-specific ligand (3-hydroxyflavone) is used to evaluate a likely mechanism of uptake for triorganotins on cells. Finally, the laboratory results are extended to a preliminary appraisal of environmental persistence of tributyltin, which involves both uptake and degradation processes.

Author Information

Brinckman, FE
Ceramics Chemistry and Bioprocesses Group, National Bureau of Standards, Gaithersburg, MD
Olson, GJ
Ceramics Chemistry and Bioprocesses Group, National Bureau of Standards, Gaithersburg, MD
Blair, WR
Ceramics Chemistry and Bioprocesses Group, National Bureau of Standards, Gaithersburg, MD
Parks, EJ
Ceramics Chemistry and Bioprocesses Group, National Bureau of Standards, Gaithersburg, MD
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Details
Developed by Committee: E47
Pages: 219–232
DOI: 10.1520/STP34042S
ISBN-EB: 978-0-8031-5043-0
ISBN-13: 978-0-8031-0978-0