SYMPOSIA PAPER Published: 01 January 1986
STP33292S

Biochemistry of Seeded Endothelial Cells

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The beneficial effect of seeding endothelial cells on synthetic vascular conduits has been well established by Herring, Graham, Schmidt, and others. This report discusses the biochemical production and interaction of the prostaglandins, prostacyclin (PGI2) and thromboxane (TXA2). A series of animal implantations was carried out with seeded and nonseeded grafts. Animals were medicated with cyclooxygenase inhibitors and TXA2 synthase inhibitors. Analysis was performed of PGI2 and TXA2 production on seeded and nonseeded grafts. Results of this analysis indicate: (1) seeded endothelial cells in Dacron® velour grafts can synthesize PGI2, (2) the levels of PGI2 from seeded endothelial cells are far less than the adjacent carotid artery, (3) the biochemistry of PGI2 production can be modulated by various antiplatelet agents, and (4) TXA2 synthase inhibitors improve thromboresistance of seeded grafts without significant effect on PGI2 production.

Author Information

Sharp, WV
Vascular Research Laboratory, Akron City Hospital, Akron, OH
Schmidt, SP
Institute for Biomedical Engineering Research, The University of Akron, Akron, OH
Hunter, TJ
Vascular Research Laboratory, Akron City Hospital, Akron, OH
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Details
Developed by Committee: F04
Pages: 189–196
DOI: 10.1520/STP33292S
ISBN-EB: 978-0-8031-4966-3
ISBN-13: 978-0-8031-0462-4