SYMPOSIA PAPER Published: 01 January 1988
STP26260S

Environmental Chemicals and Biomembranes: Kinetics of Uptake and Influence on Membrane Functions

Source

The uptake kinetics, accumulation, and metabolism of several radioactively labeled environmental chemicals by the eucaryotic microorganism yeast were studied. The results have shown that this test system rapidly provides information about the extent of uptake and accumulation of such chemicals as a function of various external conditions. Thus, different forms of environmental hazard can be simulated.

In addition, in several cases a correlation between inhibition of functional membrane proteins (adenosine triphosphatase and transport systems) and reduction of the cell growth rate was observed, which suggests that the toxicity of an environmental chemical may often be caused by the result of an interaction with important membrane components. The agreement of these results with acute toxicity data from the literature indicate that yeast is suitable for detecting potential hazards to higher organisms from chemicals.

Author Information

Ahlers, J
Federal Environmental Agency, Berlin, Federal Republic of Germany
Rösick, E
Institut für Biochemie und Molekularbiologie, Freie Universität Berlin, Berlin, Federal Republic of Germany
Stadtlander, K
Institut für Biochemie und Molekularbiologie, Freie Universität Berlin, Berlin, Federal Republic of Germany
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Details
Developed by Committee: D19
Pages: 106–119
DOI: 10.1520/STP26260S
ISBN-EB: 978-0-8031-5057-7
ISBN-13: 978-0-8031-1165-3