SYMPOSIA PAPER Published: 01 January 1990
STP26069S

Design Criteria for Safety in the Isolation and Purification of Antibiotics and Biologically Active Compounds

Source

A summary is presented of safety-related design considerations and practices in the isolation and purification of antibiotics and other biologically active compounds from fermentation broths, as practiced by Merck & Co., Inc., in current production operations.

Profiles of physical activity are established on process streams, isolated intermediates, and the final bulk active compound. Design criteria for worker protection are developed based on these profiles.

Author Information

Paul, EL
Merck Sharp & Dohme Research Laboratories, Rahway, NJ
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Details
Developed by Committee: E48
Pages: 65–73
DOI: 10.1520/STP26069S
ISBN-EB: 978-0-8031-5115-4
ISBN-13: 978-0-8031-1264-3