SYMPOSIA PAPER Published: 01 January 1994

The Effect of Calcium Phosphate Ceramic Composition and Structure on In Vitro Precipitation Reactions


The formation of a biologically equivalent carbonated apatite on the surface of synthetic calcium phosphate ceramics (CPC) may be an important step leading to bonding with bone. Reactions of several single phase CPCs upon immersion into a simulated physiological solution (SPS) with an electrolyte composition of human plasma were determined.The CPCs covered a wide range of stabilities from hydroxyapatites (HA) to metastable tricalcium phosphates (TCP) and tetracalcium phosphate (TTCP). Changes in chemical compositions of SPS and infrared spectral features after CPC immersion were analyzed. New phase formation was observed on all the CPCs. However, kinetics, compositions, and structures of the new phases were significantly different.

The studied CPCs can be characterized by the time to new phase formation in vitro: it was found to increase in the order: not well crystallized (wc) HAS

Author Information

Ducheyne, P
University of Pennsylvania, Philadelphia, PA
Radin, S
University of Pennsylvania, Philadelphia, PA
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Developed by Committee: F04
Pages: 140–148
DOI: 10.1520/STP25189S
ISBN-EB: 978-0-8031-5266-3
ISBN-13: 978-0-8031-1854-6