Oxygen systems and components have hazards associated with the ignitability and flammability of the constituent materials. The NASA Johnson Space Center White Sands Test Facility developed a method for analyzing the hazards of oxygen systems and components. Using this method, material flammability and the risks associated with various ignition modes were addressed. In addition, secondary hazards, such as those caused by seal leakage and the formation of oxygen-enriched environments exterior to pressure-retaining components were addressed. This hazards analysis method is presented as a systematic investigation tool and as a means of training individuals on the nature and level of severity of oxygen-enriched combustion. Three case studies drawn from work performed at the NASA Johnson Space Center White Sands Test Facility are presented. These case studies were conducted on a space flight component, an aircraft flight system, and a facility installation.