The influence of aluminum and titanium on the helium bubble microstructure formation in nickel and its alloys was investigated using transmission electron microscopy (TEM), thermal desorption spectroscopy (TDS), electrical resistance, and microhardness measurements. The helium implantation was carried out at room temperature (cold implantation) and at 750°C (high-temperature implantation) up to dose 5 ∙ 1020 m-2. The materials used were nickel base alloys with aluminum content of 0 to 7.5 wt.% and with titanium content of 0 to 8.3 wt.%. A substantial influence of aluminum and titanium on the helium bubble microstructure parameters has been established. The results are discussed in terms of helium trapping in the solution taking into account the formation of a secondary phase.