Methods are described for the administration of drugs and the collection of biological samples for pharmacokinetic studies in free-swimming fish. These methods use indwelling stomach tubes for gavage, aortic cannulation for blood procurement, and catheters for urine collection. This system in free-swimming animals employs a gravity-weight dependent cannula-catheter tending system to maintain preparation integrity.
Oxolinic acid pharmacokinetics were compared between caudal peduncular venipuncture and the described aortic cannulation based dose administration and sampling method. Caudal peduncular venipuncture methods resulted in a longer t½α redistribution phase, greater whole body clearances, and a shorter t½β as compared to aortic cannulation. These results suggest that the method of intravascular drug administration and sampling can significantly alter the apparent pharmacokinetics of drugs in fish.
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