SYMPOSIA PAPER Published: 01 January 1994

High Strain Rate Testing and Structural Analysis of Pericardial Bioprosthetic Materials


Characterization of the viscoelastic behavior of pencardial biomatenals for heart valve or patching applications demands testing under loading times or frequencies typical of those that occur in physiological function or in a bioprosthetic device We have used a servo-hydraulic testing system to evaluate the behavior of these materials under loading times as low as 0.05 s, frequencies up to 10 Hz and strain rates exceeding 24 000 %/min Mechanical tests included large deformation cyclic loading, stress relaxation experiments, and small deformation forced vibration This paper reviews our expenence with these tests, interpreted using results from collagen denaturation temperature testing and biochemical analysis, in three distinct studies: (1) examination of the effects of glutaraldehyde, poly (glycidyl ether) (a diepoxide compound), and cyanamide on bovine pericardium, (2) comparison of bovine and porcine pericardia, and (3) evaluation of the effects of extraction of cellular components from bovine pericardium These tools provide better means toward understanding the viscoelastic properties of these materials and the structural/functional relationships that determine those properties.

Author Information

Lee, JM
Centre for Biomaterials, University of Toronto, Toronto, Ontario, Canada
Haberer, SA
Instron Canada, Burlington, Ontario, Canada
Pereira, CA
Centre for Biomaterials, University of Toronto, Toronto, Ontario, Canada
Naimark, WA
Centre for Biomaterials, University of Toronto, Toronto, Ontario, Canada
Courtman, DW
University of Toronto, Conacher Research Wing, Toronto General Hospital, Toronto, Ontario, Canada
Wilson, GJ
The Hospital for Sick Children, Toronto, Ontario, Canada
Price: $25.00
Contact Sales
Reprints and Permissions
Reprints and copyright permissions can be requested through the
Copyright Clearance Center
Developed by Committee: F04
Pages: 19–42
DOI: 10.1520/STP18091S
ISBN-EB: 978-0-8031-5261-8
ISBN-13: 978-0-8031-1894-2