A comprehensive protocol was developed and practiced to evaluate the suitability of non-ozone depleting degreasers for oxygen cleaning applications. Of particular concern in the protocol were methodologies employed to examine the specific properties, including cleaning effectiveness factor, non-volatile residue, chemical compatibility and oxygen compatibility, of various degreasing agents. Using this protocol, a number of cleaning agents including aqueous degreasers, chlorinated solvents, terpenes and hydrocarbons were evaluated for oxygen service. As baseline information, 1,1,1-trichloroethane and D.I. water were also evaluated and their properties compared with those of the non-ozone depleting degreasers. According to the evaluation results, solvent-type degreasers generally exhibited better performance than aqueous-type degreasers in cleaning property, corrosion property and oxygen compatibility property. D.I. water at 160°F was found to yield unsatisfactory cleaning efficiency even with the aid of ultrasonic agitation. Among the solvent degreasers evaluated, chlorinated solvents including trichloroethylene and methylene chloride were shown to possess the best properties. Depending upon individual's needs and the type of degreaser to be selected, this protocol can be adopted in part or in full to evaluate the suitability of a degreaser for oxygen cleaning.