This paper provides fatigue crack growth information at low crack growth rates for two sheet titanium alloys: β-21S, a β alloy, and Ti-62222, an α + β alloy. Room (25°C) and elevated temperature (175°C) fatigue crack growth tests at two different stress ratios, R = 0.1 and 0.5, were performed. Effects of temperature and stress ratio were evaluated in order to study the complex interaction between fatigue, environment, and loading conditions. Crack-opening load was measured throughout the test from automated compliance measurements and was used to adjust fatigue crack growth data for crack closure. For β-21S, fatigue crack growth rates were similar at 175 and 25°C at a stress ratio of 0.1, while crack growth rates were lower at 175 versus 25°C at a stress ratio of 0.5 for the same nominal ΔK. Concepts associated with crack closure accounted for this as crack growth rates were found to be higher at 175°C than 25°C for both stress ratios when plotted as a function of ΔKeff, showing a temperature dependency on crack growth rate. For Ti-62222, fatigue crack growth rates were comparable between 25 and 175°C for R = 0.5, but were different at R = 0.1 where crack closure was observed at 175°C. Fatigue crack growth behavior of these two titanium alloys was comparable for all loading and temperature conditions.