SYMPOSIA PAPER Published: 01 January 1999

Endocrine Disruption, Organochlorine Pesticides, and Human Development: An Overview


The current scientific knowledge suggests that numerous anthropogenic substances in the environment potentially disrupt the endocrine system in humans, thereby, causing severe deleterious effects. The mechanisms of action of these chemicals are presently not well understood. A model for the developmental effects of these substances is largely based on diethylstilbestrol, a potent synthetic estrogen, that is known to induce morphological and physiological changes in the reproductive tracts of both men and women. Since several organochlorine pesticides have been identified as estrogenic and/or anti-androgenic, it is imperative to reassess the existing developmental and reproductive toxicity databases of these chemicals. This paper provides a critical review of available toxicological data, and also identifies important research needs for the health risk assessment of pre- and post-natal exposures to endocrine-disrupting organochlorine pesticides.

Author Information

Adeshina, F
National Center for Environmental Assessment, U.S. Environmental Protection Agency, Cincinnati, OH
Kueberuwa, SS
Research Triangle Institute, Research Triangle Park, NC
Price: $25.00
Contact Sales
Reprints and Permissions
Reprints and copyright permissions can be requested through the
Copyright Clearance Center
Developed by Committee: E47
Pages: 271–285
DOI: 10.1520/STP15808S
ISBN-EB: 978-0-8031-5408-7
ISBN-13: 978-0-8031-2618-3