SYMPOSIA PAPER Published: 01 January 1998

Tc Bioassay: A Direct Comparison of Liquid Scintillation Radiation Detection and ICP-MS Mass Detection of the Tc Isotope


A means of analyzing 99Tc in urine by inductively coupled plasma mass spectrometry (ICP-MS) has been developed. Historically, 99Tc analysis was based on the radiometric detection of the 293 keV Emax. beta decay product by liquid scintillation or gas flow proportional counting. A separation scheme for 99Tc detection by ICP-MS is given and is proven to be a sensitive and robust analytical alternative. A comparison of methods using radiometric and mass quantitation of 99Tc has been conducted in water, artificial urine, and real urine matrices at activity levels between 700 and 2200 dpm/L. Liquid scintillation results based on an external standard manual quench correction and an automatic quench curve correction method are compared with results obtained by ICP-MS. Each method produced accurate results; however, the precision of the ICP-MS results is superior to that of liquid scintillation results.

Author Information

Lewis, LA
Analytical Services Organization, Lockheed Martin Energy Systems, Inc., Oak Ridge, TN
Schweitzer, GK
University of Tennessee, Knoxville, TO
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Developed by Committee: C26
Pages: 99–110
DOI: 10.1520/STP15730S
ISBN-EB: 978-0-8031-5390-5
ISBN-13: 978-0-8031-2034-1