SYMPOSIA PAPER Published: 01 January 2000

Modulation of Pore Topography of Tissue Engineering Constructs


Absorbable materials can be used in tissue engineering to provide a porous template into which cells can be dispersed. The template not only serves as the delivery vehicle for implantation, but it also provides the form that the developing tissue will eventually take. The physicochemical properties of the material influence the development of cells within the template. This preliminary study assessed the effect of two template processing techniques on cellular attachment using sheep uterus smooth muscle cells and poly-1-lactide constructs. The results demonstrate that porogen selection in solvent cast, particulate-leached templates can radically change cellular attachment behavior.

Author Information

Burg, KJL
Clemson University, 501 Rhodes Engineering Research Center, Clemson, SC
Austin, CE
Carolinas Medical Center, Charlotte, NC
Swiggett, JP
Carolinas Medical Center, Charlotte, NC
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Developed by Committee: F04
Pages: 115–123
DOI: 10.1520/STP15304S
ISBN-EB: 978-0-8031-5444-5
ISBN-13: 978-0-8031-2870-5