Implantation of an orthopedic device into or onto bone induces the formation of an interface membrane separating the one from the other. The histological reaction patterns described herein are those occurring in the interface membranes of a cemented arthroplasty, cementless isoelastic arthroplasty, cementless carbon-fiber/polysulfone arthroplasty, intraosseous anchorage site of a carbon-fiber composite ligament, partially biodegradable composite polylactic acid polymer/carbon plate, and stainless steel nail. The tissue response to the introduction of Taurolin into bone is also reported. Under all these circumstances, the morphological findings are rather monotonous, inasmuch as inflammatory, granulomatous, and cicatrizing changes are induced by the implanted foreign materials. The authors suggest that it is not the uniqueness of any one implant component which is responsible for the development of the interface membrane but rather that one or more diverse, nonspecific, biologically indigestible wear particles, released at the bone/implant interface, trigger the self-perpetuating growth of the interface membrane.