The objectives of the study were to determine the effectiveness of a) water-repellent cotton garments and b) constant flow valve (CFV) in reducing pesticide exposure of applicators using knapsack sprayers. Fluorochemical finish was applied to cotton fabrics suitable for a) pants and shirt and b) kurta and pajama (traditional garment worn by males in India). Based on the pre-study results, a modified pants and shirt design was selected for the field trials. Eight pesticide applicators wore garments with and without finish during two spraying sessions. Field-strength chlorpyrifos was applied to red gram crop using a) knapsack sprayer and b) knapsack sprayer retrofitted with a CFV. A cotton knit collector layer was worn under the garments to assess the penetration of the pesticide through the fabric. The cotton garments and knit collector layers were extracted in acetone and analyzed using gas chromatography. Results indicate that cotton twill fabrics with the finish were more effective in reducing the amount of chlorpyrifos absorbed by the cover garment as well as the amount that penetrated through the garment when spills occurred. CFV was effective in reducing pesticide exposure of applicators using knapsack sprayers.