SYMPOSIA PAPER Published: 01 January 1993

A Receptor Binding Assay Applied to Monitoring the Neurotoxicity of Parathion to After Oral Exposure


Many naturally occurring toxins, as well as pesticides, metals, and other compounds that occur in our environment from anthropogenic activities, stimulate or antagonize neuro-receptors to produce acute and/or chronic toxicities. Recent advances in laboratory instrumentation and the availability of a variety of radiolabeled ligands and type-specific drugs for numerous receptors make it possible to easily screen large numbers of samples and detect changes in sensitivity and density of receptor types and subtypes. A receptor binding assay for examining the chronic dietary toxicity of parathion will be used as a model to describe the methodology.

Author Information

Jett, DA
Patuxent Wildlife Research Center, Laurel, MD
Eldefrawi, AT
University of Maryland School of Medicine, Baltimore, MD
Eldefrawi, ME
University of Maryland School of Medicine, Baltimore, MD
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Developed by Committee: E47
Pages: 253–262
DOI: 10.1520/STP13159S
ISBN-EB: 978-0-8031-5257-1
ISBN-13: 978-0-8031-1485-2