We used albino Xenopus laevis embryos to test the correlation of a short-term, cellular, multiple-endpoint assay (Cell Health Assay of Water Quality- CHAWQ) with a 96 hour assay FETAX (Frog Embryo Teratogenicity Assay: Xenopus). We describe the hardware and instrumentation to perform the assay. We also describe the endpoints and methods to measure them. Exemplary endpoint measurements are presented: 6-Aminonicotinamide produced a decrease in the membrane potential of the embryo as measured by dye fluorescence. A potato glycoalkaloid, α-chaconine, increased dye fluorescence due to intracellular pH. Measurements of DNA using fluorescent dyes showed a normal increase in DNA until gastrulation. A clastogen — triethylenemelamine- was detected with hex-bisbenzamide dye. These data suggest that the CHAWQ assay may contain endpoints that predict acute or chronic macroscopic effects on an organism.