SYMPOSIA PAPER Published: 01 January 1994

Head Injured Patients Who Talk Before Deterioration or Death: The TADD Syndrome


A review of a class of head injured patients who display a lucid interval before onset of coma which defines an important category of brain trauma. A hypothesis explaining the mechanism of this syndrome (T.A.D.D.) is developed on the basis of in-vitro testing of venous and arterial responses to tensile strains and the relevant clinico-pathologic data are reviewed. Venospasm is proposed as the cause of secondary ischemic hypoxia associated with a high incidence of acute subdural hematomas and brain swelling. Suggestions for further testing of this hypothesis and implications for preventive management are discussed.

Author Information

Ommaya, AK
Center for Interdisciplinary Brain Research (C.I.B.R.), Bethesda, MD
Thibault, LE
University of Pennsylvania, Philadelphia, PA
Boock, RJ
University of Pennsylvania, Philadelphia, PA
Meaney, DF
University of Pennsylvania, Philadelphia, PA
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Developed by Committee: F08
Pages: 287–303
DOI: 10.1520/STP12820S
ISBN-EB: 978-0-8031-5282-3
ISBN-13: 978-0-8031-1886-7