The proposed standard practice is derived from the standard method E2524 Standard Test Method for Analysis of Hemolytic Properties of Nanoparticles, first approved in 2008 and reapproved with no changes in 2013. The practice is intended to guide researchers in conducting the biological characterization of nanomaterials. The change in format from standard method to standard practice is needed due to the logistical challenges with conducting inter-laboratory studies aimed at defining the precision and bias of the method. Standard practices are more suitable for guiding researchers in the absence of nanoparticle standard reference materials and standardized human matrix (blood, bone marrow, kidney, and liver cells).
Developed by Subcommittee: E56.03
Staff Manager: Frank McConnell
Date Initiated: 07-20-2021
Technical Contact: Marina Dobrovolskaia
Ballot: E56 (21-04)
Status: Will Reballot Item