The paper contains an extensive, richly illustrated literature study, theoretical studies, and practical work on current development trends of technical support for dental prosthetics. Dentistry 4.0 is the concept closely inspired by the highest stage Industry 4.0 of the industrial revolution. An augmented holistic Industry 4.0 model, which takes into account all other aspects, i.e., materials, processes, and technological machines and their development and informatics service, was developed and presented. The basis for consideration is the analysis of the disease in the human stomatognathic system and the possibility of prosthetic treatment in the event of a partial or total loss of natural dentition. In several centers, independent work on the popularization of individual implants manufactured using information obtained using conical beam computed tomography (CBCT) is carried out. The developed procedure requires one to make a three-dimensional bone base model based on the CBCT tomogram and its connection with the three-dimensional model of the dentition and soft tissues in the oral cavity, prepared on the basis of impression material, and most preferably a three-dimensional scan directly from the mouth. The presented and fully digitized approach is a radical turnaround in both clinical procedures and the method of technical implant preparation using Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) methods and additive manufacturing technologies (AMT), including mainly Selective Laser Sintering (SLS) and stereolithography (SLA). The concept of hybrid multilayer biological-engineering composites is much more technologically advanced. The application of the principles of the augmented holistic Industry 4.0 model in modern dental engineering, according to the analysis, indicates a change in the traditional relationship between a dentist and dental engineer. The practical application of the Dentistry 4.0 approach is illustrated by projects regarding the manufacturing of a few dental restorations. The general conclusion indicates that the implementation of the ideas of Dentistry 4.0 following the assumptions of the augmented holistic model Industry 4.0 is inevitable and extremely beneficial.