Journal Published Online: 01 February 2019
Volume 47, Issue 2

A Comprehensive Study and Optimization of Magnetic Nanoparticle Drug Delivery to Cancerous Tissues via External Magnetic Field



Magnetic drug delivery to cancerous tissue as a noninvasive method is a promising cancer therapy. Several complex phenomena and parameters are involved in guiding nanoparticles to the targeted tissue and guaranteeing a predetermined distribution. A comprehensive Euler–Lagrangian method is utilized to simulate a realistic process of nanoparticle delivery and deposition in a cancerous tissue. Non-Newtonian and conductive blood flow in a typical vessel through a cancerous tissue in the presence of an external magnetic field is numerically modeled (both Lorentz and magnetization forces are considered). The cancerous tissue is assumed to be a multizone region with necrotic and live cell blocks. The effect of blood delivery to tissue cells via capillary vessels and blood drainage by the lymphatic system is taken into account. Particle paths and deposition are obtained using the contribution of all forces involved. The effects of Reynolds number (Re), magnetic number, addition of second magnetic source, and distribution of particles are also investigated. For all investigated conditions, the optimum magnetic number to maximize deposition is obtained.

Author Information

Roohi, Reza
Department of Mechanical Engineering, Fasa University, Fasa, Iran
Emdad, Homayoun
School of Mechanical Engineering, Shiraz University, Shiraz, Iran
Jafarpur, Khosrow
School of Mechanical Engineering, Shiraz University, Shiraz, Iran
Pages: 23
Price: $25.00
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Stock #: JTE20180450
ISSN: 0090-3973
DOI: 10.1520/JTE20180450