Different technologies, namely foamed asphalt, synthetic waxes, zeolites, and chemical additives, are used to produce warm mix asphalt (WMA). This study was undertaken to evaluate the effect of using different amounts of an amine-based chemical WMA additive on the rheology, performance grade (PG), and moisture-induced damage potential of an asphalt binder (PG 58-28). Superpave specifications were used to evaluate the rheological properties and PG of the asphalt binder. Also, a mechanistic approach-based on the surface free energy (SFE) method was used to evaluate the moisture-induced damage potential of the asphalt binder combined with commonly used aggregates in an asphalt mix. It was found that the dynamic viscosity of the asphalt binder was not significantly affected after blending it with the WMA additive. It was also observed that the Superpave high-temperature PG and the rutting factor did not reduce by an increase in the WMA additive content. However, the continuous low-temperature PG of the asphalt binder decreased with an increase in the amount of WMA additive. Furthermore, it was found that the fatigue resistance increased after blending the binder with the WMA additive. The SFE results of the asphalt binder revealed that the WMA additive used in this study reduced the moisture-induced damage potential of the asphalt mixes. However, the extent of this improvement was found to largely depend on the aggregate type. The outcomes of this study are expected to help better understand the influence of amine-based chemical WMA additives on rheological and long-term performance of asphalt mix.