Journal Published Online: 15 June 2007
Volume 35, Issue 6

Methodology for Evaluating Candidate Geometric Reference Scaffolds



Along with the ASTM Division IV subcommittee on Tissue Engineered Medical Products, the National Institute of Standards and Technology is developing a geometric reference scaffold. This paper describes the methodology applied to the three different types of candidate reference scaffolds to quantify their structure and rank them according to quality metrics. In this work, we detail this methodology using the candidate reference scaffold produced by stereolithography. We perform X-ray micro-computed tomography on three of the manufactured scaffolds and compute total porosity, pore size distribution, and pore length for each. We compare these quantities to those of the model scaffold using statistical measures of variational distance, relative uncertainty, and uniformity. Through this evaluation, we find that the scaffold produced by stereolithography agrees well with its model and merits further consideration as a reference scaffold.

Author Information

Dunkers, Joy
Polymers Division, National Institute of Standards and Technology, MD, Gaithersburg
Leigh, Stefan
Mathematical and Computational Sciences Division, NIST, MD, Gaithersburg
Dean, David
Department of Neurological Surgery, Case Western Reserve University, Ohio, Cleveland
Cooke, Malcolm
College of Engineering, University of Texas at El Paso, El Paso, TX
Ketcham, Richard
Jackson School of Geosciences, University of Texas at Austin, Austin, TX
Cicerone, Marcus
Polymers Division, NIST, MD, Gaithersburg
Pages: 8
Price: $25.00
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Stock #: JTE100598
ISSN: 0090-3973
DOI: 10.1520/JTE100598