Sir: Krane et al. (1) contest the conclusion of our study of the “CODIS STR Loci Data from 41 Sample Populations” (2), that “there was little evidence for departures from Hardy-Weinberg expectations (HWE) in any of the populations” on the grounds that: (a) our application of the Bonferroni adjustment for multiple testing to our data on 12 to 13 loci, studied in each of the 41 populations, is inappropriate; (b) we disregarded the “significant” clustering of departures from HWE in two populations (Salishan and Navajo); and (c) we failed to pay attention to the distinctiveness of the Native American populations to explain the clusters of deviant test results in these populations. Further, Krane et al. (1) contend that our data “provides significant evidence that at least three loci in Navajos (FGA, D7S820, and TH01) as well as Salishans (D3S1358, FGA, and D7S820) do not adhere to HWE” and hence, “the product rule should not be used to estimate the rarity of genotypes involving those loci in those populations unless corrective factors are involved.”
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