Journal Published Online: 01 January 1998
Volume 43, Issue 1

Comparative Determination of 2-Carbomethoxy-3-Alkyloxy- and Heteroaroyloxy-Substituted Tropanes in Illicit South American Cocaine Using Capillary Gas Chromatography-Single Ion Monitoring

CODEN: JFSCAS

Abstract

Methodology is presented for the isolation and comparative determination of 16 alkyloyl and 2 heteroaroyl ecgonine methyl esters in illicit cocaine samples. These trace-level alkaloids, five of which are reported for the first time, were partially isolated from cocaine using alumina column chromatography and recrystallization and determined using capillary gas chromatography-mass spectrometry using selected ion monitoring. Acetoxy-, propionoyl-, isobutyroyl-, butyroyl-, 2-methylbutyroyl-, isovaleroyl-, valeroyl-, senecioyl-, trans-4-hexenoyl-, tigloyl-, hexanoyl-, 3′-furanoyl-, trans-2-hexenoyl-, 2′-furanoyl-, trans-3-heptenoyl-, cis-, trans-; trans-, cis-; and trans-, trans-2,4-hexadienoyl- ecgonine methyl esters were detected at levels less than 1 × 10−5 % (w/w relative to cocaine).

Author Information

Casale, JF
U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, McLean, Virginia
Moore, JM
U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, McLean, Virginia
Odeneal, NG
U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, McLean, VA
Pages: 8
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Stock #: JFS16099J
ISSN: 0022-1198
DOI: 10.1520/JFS16099J