Journal Published Online: 01 May 2000
Volume 45, Issue 3

The Comparison of Toluene Determination Between Headspace-Solid Phase Microextraction and Headspace Methods in Glue-Sniffer's Blood and Urine Samples



An accurate and simple method was developed to determine the level of toluene in urine and blood quantitatively by using the gas chromatography/mass spectrometry (GC/MS) with headspace—solid phase microextraction (HS-SPME) technique. An assembly of SPME with a replaceable extraction fiber, coated with 100 μm polydimethylsiloxane, was used. The detection limit of toluene in blood and urine with HS-SPME technique was 10 times higher than that with headspace (HS) technique. To compare the HS-SPME with HS technique for the determination of toluene in biological fluids, blood and urine samples from glue sniffers were analyzed by both methods. The level of toluene by the two techniques was highly correlated: the correlation coefficient (r2) between the two sets of values were 0.98 and 0.96 in urine and blood, respectively.

Author Information

Kim, NY
National Institute of Scientific Investigation, Seoul, South Korea
Park, SW
National Institute of Scientific Investigation, Seoul, South Korea
Pages: 6
Price: $25.00
Reprints and Permissions
Reprints and copyright permissions can be requested through the
Copyright Clearance Center
Stock #: JFS14754J
ISSN: 0022-1198
DOI: 10.1520/JFS14754J