Journal Published Online: 01 January 1999
Volume 44, Issue 1

A Study Involving Venlafaxine Overdoses: Comparison of Fatal and Therapeutic Concentrations in Postmortem Specimens

CODEN: JFSCAS

Abstract

The distribution and redistribution of venlafaxine were investigated in two overdoses and several cases involving the therapeutic use of venlafaxine. Blood, liver, bile vitreous humor, urine and gastric contents were analyzed using high performance liquid chromatography with ultraviolet detection. Blood concentrations of venlafaxine in the two overdose cases were 53 mg/L and 78 mg/L. Comparison of venlafaxine concentrations in blood samples taken at different times after death revealed increases in concentrations over time, suggesting the possible postmortem redistribution of venlafaxine.

Author Information

Jaffe, PD
Victorian Institute of Forensic Medicine and Department of Forensic Medicine, Monash University, Melbourne, Victoria, Australia
Batziris, HP
Victorian Institute of Forensic Medicine and Department of Forensic Medicine, Monash University, Melbourne, Victoria, Australia
Hoeven, P van der
Gippsland Pathology Service, Traralgon, Victoria, Australia
DeSilva, D
Mildura Base Hospital, Barratt & Smith Pathology, Mildura, Victoria, Australia
McIntyre, IM
Victorian Institute of Forensic Medicine and Department of Forensic Medicine, Monash University, Melbourne, Victoria, Australia Monash University
Pages: 4
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Stock #: JFS14434J
ISSN: 0022-1198
DOI: 10.1520/JFS14434J