Standard Active Last Updated: Jan 31, 2017
ASTM D5806-95(2017)

Standard Test Method for Disinfectant Quaternary Ammonium Salts by Potentiometric Titration

Significance and Use

5.1 This test method is used to determine the percent actives in each type of the disinfectant quaternary ammonium salts, and also in the disinfectant products. Quaternary ammonium compounds being the active ingredients in disinfectant-type products require accurate determination to assess the cost and antimicrobial performance of such products.


1.1 This test method covers a potentiometric titration procedure for determining active matter in disinfectant quaternary ammonium salts. This test method is intended for the analysis of quaternary ammonium salts used as disinfectants, and only applies to the following commonly used quaternary ammonium salts: n-alkyldimethylbenzylammonium chloride (see Fig. 1), cetyltrimethylammonium chloride, and a blend of n-octyldecyl dimethylammonium chloride, di-n-octyl dimethylammonium chloride, and di-n-decyldimethyl ammonium chloride (see Fig. 2). Also, this test method can be applied to the analysis of disinfectant type products where the formula ingredients are known and the quaternary ammonium salt is one of the above. Interferences such as amines oxides and betaines present in disinfectant formulations were not tested.

X   =   chloride, and R   =   aliphatic, normal C8 − C22.

1.2 This disinfectant quaternary ammonium salt conforms to the structures in Fig. 1 and Fig. 2.

1.3 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. For specific precautionary information, see Section 8.

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Book of Standards Volume: 15.04
Developed by Subcommittee: D12.12
Pages: 4
DOI: 10.1520/D5806-95R17
ICS Code: 71.100.35