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    ASTM F451 - 21

    Standard Specification for Acrylic Bone Cement

    Active Standard ASTM F451 | Developed by Subcommittee: F04.11

    Book of Standards Volume: 13.01


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    Abstract

    This specification covers self-curing resins used primarily for the fixation of internal orthopedic prostheses. While a variety of copolymers and comonomers may be incorporated, the composition of the set cement shall contain poly(methacrylic acid esters) as its main ingredient. The mixture may be used in either the predough or dough stage. This specification covers compositional, physical performance, and biocompatibility as well as packaging requirements. Materials shall be tested and shall conform to specified values of appearance, stability, sterility, viscosity, intrusion and compressive strength. The biocompatibility of acrylic bone cement as it has been traditionally formulated and used is also detailed.

    This abstract is a brief summary of the referenced standard. It is informational only and not an official part of the standard; the full text of the standard itself must be referred to for its use and application. ASTM does not give any warranty express or implied or make any representation that the contents of this abstract are accurate, complete or up to date.

    1. Scope

    1.1 This specification covers self-curing resins used primarily for the fixation of internal orthopedic prostheses. The mixture may be used in either the pre-dough or dough stage in accordance with the manufacturer’s recommendations.

    1.2 Units of pre-measured powder and liquid are supplied in a form suitable for mixing. The mixture then sets in place.

    1.3 While a variety of copolymers and comonomers may be incorporated, the composition of the set cement shall contain poly(methacrylic acid esters) as its main ingredient.

    1.4 This specification covers compositional, physical performance, and biocompatibility as well as packaging requirements. The biocompatibility of acrylic bone cement as it has been traditionally formulated and used has been reported in the literature (1, 2).2

    1.5 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

    1.6 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.

    1.7 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.


    2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.

    ASTM Standards

    D638 Test Method for Tensile Properties of Plastics

    D695 Test Method for Compressive Properties of Rigid Plastics

    D1193 Specification for Reagent Water

    D3835 Test Method for Determination of Properties of Polymeric Materials by Means of a Capillary Rheometer

    D5296 Test Method for Molecular Weight Averages and Molecular Weight Distribution of Polystyrene by High Performance Size-Exclusion Chromatography

    D5630 Test Method for Ash Content in Plastics

    E169 Practices for General Techniques of Ultraviolet-Visible Quantitative Analysis

    E275 Practice for Describing and Measuring Performance of Ultraviolet and Visible Spectrophotometers

    F619 Practice for Extraction of Materials Used in Medical Devices

    F748 Practice for Selecting Generic Biological Test Methods for Materials and Devices

    F749 Practice for Evaluating Material Extracts by Intracutaneous Injection in the Rabbit

    F756 Practice for Assessment of Hemolytic Properties of Materials

    F763 Practice for Short-Term Screening of Implant Materials

    F813 Practice for Direct Contact Cell Culture Evaluation of Materials for Medical Devices

    F895 Test Method for Agar Diffusion Cell Culture Screening for Cytotoxicity

    F981 Practice for Assessment of Compatibility of Biomaterials for Surgical Implants with Respect to Effect of Materials on Muscle and Insertion into Bone

    ANSI/ADA Standard

    No. 15 Specification for Acrylic Resin Teeth

    ISO Standards

    ISO 5833 Implants for SurgeryAcrylic Resin Cements

    ISO 80000-9 Quantities and UnitsPart 9: Physical Chemistry and Molecular Physics


    ICS Code

    ICS Number Code 11.040.40 (Implants for surgery, prothetics and orthotics)

    UNSPSC Code

    UNSPSC Code 42295466(Surgical bone cement)


    Referencing This Standard
    Link Here
    Link to Active (This link will always route to the current Active version of the standard.)

    DOI: 10.1520/F0451-21

    Citation Format

    ASTM F451-21, Standard Specification for Acrylic Bone Cement, ASTM International, West Conshohocken, PA, 2021, www.astm.org

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