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This test method has been designed to examine the subchronic oral toxicity of a test substance during a 90-day period of continuous oral exposure to rats (Rattus norvegicus) following initial acute toxicity tests.
Formerly under the jurisdiction of Committee E47 on Biological Effects and Environmental Fate, this test method was withdrawn in February 2010, because other guidelines currently exist.
1.1 This test method has been designed to examine the subchronic oral toxicity of a test substance during a 90-day period of continuous oral exposure to rats (Rattus norvegicus) following initial acute toxicity tests.
1.2 The values stated in SI units are to be regarded as the standard. The values given in parentheses are for information only.
1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.
2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.
E609 Terminology Relating to Pesticides
E1163 Test Method for Estimating Acute Oral Toxicity in Rats
Federal StandardsTitle 40, Code of Federal Regulations (CFR), Toxic Substance Control Act, Part 792, Good Laboratory Practice Standards
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ASTM E1372-95(2003), Standard Test Method for Conducting a 90-Day Oral Toxicity Study in Rats (Withdrawn 2010), ASTM International, West Conshohocken, PA, 2003, www.astm.orgBack to Top