ASTM D6122 - 18

    Standard Practice for Validation of the Performance of Multivariate Online, At-Line, and Laboratory Infrared Spectrophotometer Based Analyzer Systems

    Active Standard ASTM D6122 | Developed by Subcommittee: CONTROL

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    Abstract

    D02.25

    This abstract is a brief summary of the referenced standard. It is informational only and not an official part of the standard; the full text of the standard itself must be referred to for its use and application. ASTM does not give any warranty express or implied or make any representation that the contents of this abstract are accurate, complete or up to date.

    1. Scope

    1.1 This practice covers requirements for the validation of measurements made by laboratory or process (online or at-line) near- or mid-infrared analyzers, or both, used in the calculation of physical, chemical, or quality parameters (that is, properties) of liquid petroleum products and fuels. The properties are calculated from spectroscopic data using multivariate modeling methods. The requirements include verification of adequate instrument performance, verification of the applicability of the calibration model to the spectrum of the sample under test, and verification that the degree of agreement between the results calculated from the infrared measurements and the results produced by the PTM used for the development of the calibration model meets user-specified requirements. Initially, a limited number of validation samples representative of current production are used to do a local validation. When there is an adequate number of validation samples with sufficient variation in both property level and sample composition to span the model calibration space, the statistical methodology of Practice D6708 can be used to provide general validation of this equivalence over the complete operating range of the analyzer. For cases where adequate property and composition variation is not achieved, local validation continues to be used.

    1.1.1 For some applications, the analyzer and PTM are applied to the same material. The application of the multivariate model to the analyzer output (spectrum) directly produces a PPTMR for the same material for which the spectrum was measured. The PPTMRs are compared to the PTMRs measured on the same materials to determine the degree of agreement.

    1.1.2 For other applications, the material measured by the analyzer system is subjected to a consistent treatment prior to being analyzed by the PTM. The application of the multivariate model to the analyzer output (spectrum) produces a PPTMR for the treated material. The PPTMRs based on the analyzer outputs are compared to the PTMRs measured on the treated materials to determine the degree of agreement.

    1.2 Multiple physical, chemical, or quality properties of the sample under test are typically predicted from a single spectral measurement. In applying this practice, each property prediction is validated separately. The separate validation procedures for each property may share common features, and be affected by common effects, but the performance of each property prediction is evaluated independently. The user will typically have multiple validation procedures running simultaneously in parallel.

    1.3 Results used in analyzer validation are for samples that were not used in the development of the multivariate model, and for spectra which are not outliers or nearest neighbor inliers relative to the multivariate model.

    1.4 When the number, composition range or property range of available validation samples do not span the model calibration range, a local validation is done using available samples representative of current production. When the number, composition range and property range of available validation samples becomes comparable to those of the model calibration set, a general validation can be done.

    1.4.1 Local Validation: 

    1.4.1.1 The calibration samples used in developing the multivariate model must show adequate compositional and property variation to enable the development of a meaningful correlation, and must span the compositional range of samples to be analyzed using the model to ensure that such analyses are done via interpolation rather than extrapolation. The Standard Error of Calibration (SEC) is a measure of how well the PTMRs and PPTMRs agree for this set of calibration samples. SEC includes contributions from spectrum measurement error, PTM measurement error, and model error. Sample (type) specific biases are a part of the model error. Typically, spectroscopic analyzers are very precise, so that spectral measurement error is small relative to the other types of error.

    1.4.1.2 During initial analyzer validation, the compositional range of available samples may be small relative to the range of the calibration set. Because of the high precision of the spectroscopic measurement, the average difference between the PTMRs and PPTMRs may reflect a sample (type) specific bias which is statistically observable, but which are less than the 95 % uncertainty of PPTMR, U(PPTMR). Therefore, the bias and precision of the PTMR/PPTMR differences are not used as the basis for local validation.

    1.4.1.3 Based on SEC, and the leverage statistic, a 95 % uncertainty for each PPTMR, U(PPTMR) is calculated. During validation, for each non-outlier sample, a determination is made as to whether the absolute difference between PPTMR and PTMR,


    2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.

    ASTM Standards

    D86 Test Method for Distillation of Petroleum Products and Liquid Fuels at Atmospheric Pressure

    D1265 Practice for Sampling Liquefied Petroleum (LP) Gases, Manual Method

    D1319 Test Method for Hydrocarbon Types in Liquid Petroleum Products by Fluorescent Indicator Adsorption

    D3606 Test Method for Determination of Benzene and Toluene in Spark Ignition Fuels by Gas Chromatography

    D3764 Practice for Validation of the Performance of Process Stream Analyzer Systems

    D4057 Practice for Manual Sampling of Petroleum and Petroleum Products

    D4177 Practice for Automatic Sampling of Petroleum and Petroleum Products

    D5599 Test Method for Determination of Oxygenates in Gasoline by Gas Chromatography and Oxygen Selective Flame Ionization Detection

    D6299 Practice for Applying Statistical Quality Assurance and Control Charting Techniques to Evaluate Analytical Measurement System Performance

    D6708 Practice for Statistical Assessment and Improvement of Expected Agreement Between Two Test Methods that Purport to Measure the Same Property of a Material

    D7278 Guide for Prediction of Analyzer Sample System Lag Times

    D7453 Practice for Sampling of Petroleum Products for Analysis by Process Stream Analyzers and for Process Stream Analyzer System Validation

    D7717 Practice for Preparing Volumetric Blends of Denatured Fuel Ethanol and Gasoline Blendstocks for Laboratory Analysis

    D7808 Practice for Determining the Site Precision of a Process Stream Analyzer on Process Stream Material

    E131 Terminology Relating to Molecular Spectroscopy

    E275 Practice for Describing and Measuring Performance of Ultraviolet and Visible Spectrophotometers

    E456 Terminology Relating to Quality and Statistics

    E932 Practice for Describing and Measuring Performance of Dispersive Infrared Spectrometers

    E1421 Practice for Describing and Measuring Performance of Fourier Transform Mid-Infrared (FT-MIR) Spectrometers: Level Zero and Level One Tests

    E1655 Practices for Infrared Multivariate Quantitative Analysis

    E1866 Guide for Establishing Spectrophotometer Performance Tests

    E1944 Practice for Describing and Measuring Performance of Laboratory Fourier Transform Near-Infrared (FT-NIR) Spectrometers: Level Zero and Level One Tests


    ICS Code

    ICS Number Code 17.180.30 (Optical measuring instruments)

    UNSPSC Code

    UNSPSC Code 41115406(Spectrophotometers)


    Referencing This Standard
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    DOI: 05.02

    Citation Format

    ASTM D6122-18, Standard Practice for Validation of the Performance of Multivariate Online, At-Line, and Laboratory Infrared Spectrophotometer Based Analyzer Systems, ASTM International, West Conshohocken, PA, 2018, www.astm.org

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