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    Particulate Debris from Medical Implants: Mechanisms of Formation and Biological Consequences

    St. John KR
    Published: 1992

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    One of the causes or results (or both) of medical implant failure is the release of particulate material debris from the device because of wear, physical deterioration, or chemical attack by the harsh physiological environment. STP 1144 examines tissue response to particles of implant material in order to identify factors, such as materials selection, surgical protocol, implant design, or postoperative prophylactic drug treatment, that might limit debris generation or moderate the tissue response.

    19 peer-reviewed papers written by principal researchers in the field are divided into two sections: clinical experience with the generation of material debris from implants; and in vitro and in vivo models for the clinical situation and methods for generating and characterizing wear debris particles that may be used in laboratory models. For medical implant designers/orthopaedics, orthopaedic surgeons, medial libraries, and biomaterials researchers.

    Table of Contents


    Debris-Mediated Osteolysis—A Cascade Phenomenon Involving Motion, Wear, Particulates, Macrophage Induction, and Bone Lysis

    Clinical and Experimental Studies in the Biology of Aseptic Loosening of Joint Arthroplasties and the Role of Polymer Particles

    Histopathological Effects of Ultrahigh-Molecular-Weight Polyethylene and Metal Wear Debris in Porous and Cemented Surface Replacements

    Particulate-Associated Endosteal Osteolysis in Titanium-Base Alloy Cementless Total Hip Replacement

    Endosteal Osteolysis Around Well-Fixed Porous-Coated Cementless Femoral Components

    Photon Correlation Spectroscopy Analysis of the Submicrometre Particulate Fraction in Human Synovial Tissues Recovered at Arthroplasty or Revision

    Failure Mechanism of a Metal-Backed Patella: An Implant Retrieval Study

    Use of Profile Imaging to Assess Patellofemoral Congruity: Implications for Assessing Patellofemoral Wear in Total Knee Arthroplasty

    Histomorphological Reaction Patterns of the Bone to Diverse Particulate Implant Materials in Man and Experimental Animals

    Prostaglandin E2 Synthesis by the Tissue Surrounding Ultrahigh Molecular Weight Polyethylene in Different Physical Forms

    A Comparison of the Biocompatibility of Polymethyl Methacrylate Debris With and Without Titanium Debris: A Comparison of Two In Vivo Models

    Biocompatibility of Polymethyl Methacrylate With and Without Barium Sulfate in the Rat Subcutaneous Air Pouch Model

    In Vitro Activation of Monocyte Macrophages and Fibroblasts by Metal Particles

    In Vitro Cellular Activation by Fabricated and Clinically Retrieved Bone Cement Wear Particles

    Human Plasma Adsorption to Particulate Arthroplastic Component Materials In Vitro

    Correlation Between the Metal Ion Concentration and the Fretting Wear Volume of Orthopaedic Implant Metals

    Preparation, Characterization, and Animal Testing for Biocompatibility of Metal Particles of Iron-, Cobalt-, and Titanium-Based Implant Alloys

    Polymer Particles In Vivo: Distribution in the Knee, Migration to Lymph Nodes, and Associated Cellular Response Following Anterior Cruciate Ligament Replacement

    Use of an Anticollagenase Antibody to Study Synovial Cell Interactions with Particulate Material

    Author Index

    Subject Index

    Committee: F04

    DOI: 10.1520/STP1144-EB

    ISBN-EB: 978-0-8031-5202-1

    ISBN-13: 978-0-8031-1441-8