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    Effects of Unmodified Natural and Coated Silicious Earth in a Long-Term Intraperitoneal Test in Rats

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    In a long-term intraperitoneal test with rats the quantitative and qualitative effect of unmodified natural silicious earth with and without surface coating was studied. The following results were obtained: Natural silicious earth (NSE) causes distinct silicotic reactions. Surface-coating of this dust does not reduce its harmfulness, but only an initial inhibition of the silicotic reaction can be observed. The effects of natural products (silicious earth, diatomaceous earth, diatomite) as well as of amorphous synthetic silica are compared and contrasted.


    silicious earth, long term intraperitoneal test, quantitative effects, pathology, amorphous silica

    Author Information:

    Weller, W
    Silicosis Research Institute of the Bergbau-Berufsgenossenschaft, Bochum,

    Committee/Subcommittee: E34.16

    DOI: 10.1520/STP38674S