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    Considerations in the Design and Analysis of Chronic Aquatic Tests of Toxicity

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    Some considerations in the planning of toxicity tests and in the reporting of results are discussed. The need for using standardized stocks of fish and standardized data recording and data reporting procedures is argued. Standardized sheets for reporting hatchability data are presented as an example of a number of standardized data reporting sheets developed by the authors.

    We consider aspects of the statistical analysis of data arising from aquatic toxicity tests. The discussion emphasizes analyses and data displays for the interpretation of qualitative mortality and abnormality data, but the ideas pertain also to other types of data.

    The techniques discussed include preliminary graphical displays, tests for homogeneity among tanks within treatment groups, adjustments to account for tank-to-tank heterogeneity within groups, outlier detection procedures, overall tests for treatment effects, multiple comparisons and pairwise confidence intervals of treatment groups with the control group, and dose-response curve fitting with associated estimates of “safe concentrations.”


    aquatic toxicity tests, statistical methods, standardized fish stocks, standardized data reporting, hypothesis tests, outlier detection, multiple comparisons, dose-response curves, aquatic toxicology, hazard assessment

    Author Information:

    Feder, PI
    Senior research statistician, Battelle, Columbus Laboratories, Columbus, Ohio

    Collins, WJ
    Professor, Ohio State University, Columbus, Ohio

    Committee/Subcommittee: E35.14

    DOI: 10.1520/STP36709S